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Un induttore del CYP3A4, occur la rifampicina, ha ridotto del ninety% la distribuzione del tadalafil, con possibile riduzione della sua efficacia. Altri induttori del CYP3A4, occur fenobarbital, fenitoina e carbamazepina potrebbero ridurre le concentrazioni plasmatiche di tadalafil.
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Il tadalafil ha una durata d’azione superiore a quella del sildenafil e questo permette una sua singola piç somministrazione giornaliera.
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Acetildenafil together with other artificial structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of "herbal" aphrodisiac products and solutions bought around-the-counter.[forty one] These analogs have not been through any of your rigorous screening that prescription drugs like sildenafil have passed, and so have unidentified aspect-effect profiles.
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